What chronic condition is characterized by an autoimmune attack on the skin and joints?

Psoriasis is the chronic condition characterized by an autoimmune attack that primarily affects the skin but can also have implications for joints, particularly in a subtype known as psoriatic arthritis. Psoriasis manifests as red, scaly patches on the skin due to the overproduction of skin cells driven by an abnormal immune response.

In addition to the skin symptoms, individuals with psoriasis can develop psoriatic arthritis, which involves inflammation of the joints and is associated with pain and stiffness. This dual aspect of psoriasis—as a skin condition that can also affect joint health—highlights its autoimmune nature.

In contrast, rheumatoid arthritis primarily targets the joints and is distinctly different in its pathophysiology compared to psoriasis. Systemic lupus erythematosus also involves multiple organ systems and is not limited to the skin and joints. Multiple sclerosis affects the central nervous system rather than the skin or joints. Therefore, psoriasis is the most fitting answer as it encompasses an autoimmune action impacting both the skin and the joints.