Which type of blood pressure medication can precipitate gout?

Loop diuretics are known to potentially precipitate gout due to their effects on uric acid levels in the body. Diuretics increase urine production, which can lead to dehydration and concentration of uric acid in the blood. The reduction in blood volume caused by diuretics can also trigger the kidneys to reabsorb more uric acid to maintain homeostasis, resulting in elevated levels of uric acid, a key player in the pathophysiology of gout. High levels of uric acid can lead to crystal formation in joints, causing the painful inflammation characteristic of gout attacks.

Understanding this mechanism is crucial, especially for patients at risk for gout or those with a history of gout attacks, as the choice of antihypertensive medications should take into account their potential effects on uric acid metabolism.